Metabolic footprint of sepsis and septic shock: A narrative review
Anjali Mishra, Deven Juneja · 2026
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Description
Mishra and Juneja review the metabolic footprint of sepsis in this 2026 World Journal of Critical Care Medicine article. Sepsis is deadly and varied, and standard biomarkers cannot track the deep metabolic upheaval it causes. Metabolomics, the wholesale measurement of small molecules in blood and tissue, can. The authors summarize animal and human studies using magnetic resonance and mass spectrometry platforms.
Patterns recur across studies: disturbed energy production, amino-acid and lipid turnover turned upside down, failing mitochondria, and metabolites made by gut microbes. Such profiles can separate sepsis from sterile inflammation and flag patients headed for organ failure or death. The authors see promise in merging metabolomics with other omics and clinical data for precision critical care, while warning that standardization lags behind the science.
Catalog record
| CREATOR | Anjali Mishra, Deven Juneja |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |