Benchmarking Plasma Proteomics Workflows and Their Correlation to Clinical Routine Protein Assays
Anders Handrup Kverneland, Ole Østergaard, Luisa Schmidt, Mia Østergaard Johansen, Steffen Ullitz Thorsen, Ruth Frikke Schmidt, Christina Christoffersen, Jesper Velgaard Olsen · 2026
Read Benchmarking Plasma Proteomics Workflows and Their Correlation to Clinical Routine Protein Assays by Anders Handrup Kverneland, Ole Østergaard, Luisa Schmidt, Mia Østergaard Johansen, Steffen Ullitz Thorsen, Ruth Frikke Schmidt, Christina Christoffersen, Jesper Velgaard Olsen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13248009.txt.
Description
Anders Handrup Kverneland worked with seven others in two thousand twenty-six to test ways to read the proteins in blood plasma. Plasma holds hope for clues to disease. But a few proteins are so rich in it that they drown out the rest. That makes the set hard to read by mass spectrometry.
Labs cope in two ways. Some pull the rich proteins out, in Top14 depletion or with acid precipitation. Some pull rare bits in, with beads or by ultracentrifugation. The team tried top ways of each type on three blood sample types. The two ways read distinct sets. The pull-in ways read more, and more truly, but may be less steady in big groups. Ten routine lab tests were checked. Some, like C-reactive protein, matched well. Others, like albumin and transferrin, matched poorly. The way must fit the aim.
Catalog record
| CREATOR | Anders Handrup Kverneland, Ole Østergaard, Luisa Schmidt, Mia Østergaard Johansen, Steffen Ullitz Thorsen, Ruth Frikke Schmidt, Christina Christoffersen, Jesper Velgaard Olsen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |