Pathology and Genetics in a Global Cohort of Parkinsonian Disorders
Lesley Y. Wu, Tessa du Toit, Tatiana Georgiades, Eleanor J. Stafford, Kristin Levine, Zih-Hua Fang, Simona Jasaityte, Ana-Luisa Gil Martinez, Patrick Cullinane, Eduardo De Pablo-Fernandez, Cornelis Blauwendraat, Andrew B. Singleton, Sonja W. Scholz, Bryan J. Traynor, Nicholas Wood, John Hardy, Patrick Chinnery, Henry Houlden, Richard Cain, Claire Troakes, Viorica Chelban, Geidy E. Serrano, Djordje Gveric, Catriona McLean, Seth Love, Andrew King, Andrew C. Robinson, Federico Roncaroli, Claire Shepherd, Glenda Halliday, Laura Parkkinen, Christopher M. Morris, Colin Smith, Thomas G. Beach, Steve Gentleman, Thomas T. Warner, Tammaryn Lashley, Zane Jaunmuktane, Raquel Real, Huw R. Morris · 2026
Read Pathology and Genetics in a Global Cohort of Parkinsonian Disorders by Lesley Y. Wu, Tessa du Toit, Tatiana Georgiades, Eleanor J. Stafford, Kristin Levine, Zih-Hua Fang, Simona Jasaityte, Ana-Luisa Gil Martinez, Patrick Cullinane, Eduardo De Pablo-Fernandez, Cornelis Blauwendraat, Andrew B. Singleton, Sonja W. Scholz, Bryan J. Traynor, Nicholas Wood, John Hardy, Patrick Chinnery, Henry Houlden, Richard Cain, Claire Troakes, Viorica Chelban, Geidy E. Serrano, Djordje Gveric, Catriona McLean, Seth Love, Andrew King, Andrew C. Robinson, Federico Roncaroli, Claire Shepherd, Glenda Halliday, Laura Parkkinen, Christopher M. Morris, Colin Smith, Thomas G. Beach, Steve Gentleman, Thomas T. Warner, Tammaryn Lashley, Zane Jaunmuktane, Raquel Real, Huw R. Morris (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13247843.txt.
Description
Wu and a large international team compare clinical diagnoses with brain pathology and genetics across parkinsonian disorders. Their 2026 cross-sectional study draws on 3,353 brain donors who had movement-disorder diagnoses or were healthy controls. Conditions covered include Parkinson disease, dementia with Lewy bodies, progressive supranuclear palsy, multiple system atrophy, and corticobasal syndrome.
Autopsy often told a different story from the clinic. Among people diagnosed with Parkinson disease, 3.1 percent actually had supranuclear palsy pathology, while 7.1 percent of clinical supranuclear palsy cases showed Lewy body disease instead. Nearly 17 percent of clinical multiple system atrophy cases had Lewy body pathology, and corticobasal syndrome most often reflected supranuclear palsy or Alzheimer pathology. The authors also examined how variants in genes such as GBA1 and LRRK2 tracked with these pathological patterns.
Catalog record
| CREATOR | Lesley Y. Wu, Tessa du Toit, Tatiana Georgiades, Eleanor J. Stafford, Kristin Levine, Zih-Hua Fang, Simona Jasaityte, Ana-Luisa Gil Martinez, Patrick Cullinane, Eduardo De Pablo-Fernandez, Cornelis Blauwendraat, Andrew B. Singleton, Sonja W. Scholz, Bryan J. Traynor, Nicholas Wood, John Hardy, Patrick Chinnery, Henry Houlden, Richard Cain, Claire Troakes, Viorica Chelban, Geidy E. Serrano, Djordje Gveric, Catriona McLean, Seth Love, Andrew King, Andrew C. Robinson, Federico Roncaroli, Claire Shepherd, Glenda Halliday, Laura Parkkinen, Christopher M. Morris, Colin Smith, Thomas G. Beach, Steve Gentleman, Thomas T. Warner, Tammaryn Lashley, Zane Jaunmuktane, Raquel Real, Huw R. Morris |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |