A high surface area silica-supported aldehyde as a flow-compatible amine scavenger
A. Michelle Reinhardt, Jenny-Lee Panayides, Darren L. Riley · 2026
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Description
Reinhardt, Panayides, and Riley built a chemical sponge for cleaning up flowing reactions in this 2026 RSC Advances paper. In continuous-flow synthesis, leftover amines contaminate products, and a solid scavenger packed in-line can trap them. The team decorated high-surface-area SBA-15 silica with aldehyde groups through a three-step surface chemistry, confirming the coating with a battery of analyses and a color test.
The material's loading matched commercial resin scavengers, and it survived flow conditions. A twenty-two-run designed experiment varied solvent, flow rate, temperature, and amine concentration; only the solvent mattered significantly. Hydrophobic solvents gave near-total capture, while acetonitrile screened the interaction and cut efficiency to about three quarters. The authors present the scavenger as a ready in-line purification tool for flow-chemistry libraries.
Catalog record
| CREATOR | A. Michelle Reinhardt, Jenny-Lee Panayides, Darren L. Riley |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |