Single Cell Transcriptomic Atlas Reveals Cellular Heterogeneity and Molecular Mechanisms in Pediatric Airway Hyperresponsiveness Epithelium
Weiming Yang, Shunfeng Mao, Liuyang Zhou · 2026
Read Single Cell Transcriptomic Atlas Reveals Cellular Heterogeneity and Molecular Mechanisms in Pediatric Airway Hyperresponsiveness Epithelium by Weiming Yang, Shunfeng Mao, Liuyang Zhou (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13247550.txt.
Description
Yang and co-authors built a single-cell atlas of twitchy pediatric airways in this 2026 International Journal of Genomics study. Airway hyperresponsiveness, airways that overreact to triggers, underlies much childhood asthma-like disease, but averaging gene activity across whole tissue hides rare cell types. The team reanalyzed public single-cell sequencing data from bronchial brushings of affected children, clustering cells and tracing their developmental paths.
The atlas resolved the mix of epithelial and immune cells, including varied macrophage states, and highlighted variable genes tied to tissue remodeling. A network-pharmacology layer even mapped targets of a traditional herbal formula onto the cell data. The authors stress the work is hypothesis-generating computation: it needs healthy comparison tissue, fresh cohorts, and laboratory validation before guiding treatment.
Catalog record
| CREATOR | Weiming Yang, Shunfeng Mao, Liuyang Zhou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |