Case Report: Dramatic response to amivantamab plus chemotherapy in EGFR G719A–mutant lung adenocarcinoma with liver and peritoneal metastases
Jiwon Kim, Han Gyeol Kim, Seung Hyeun Lee · 2026
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Description
Jiwon Kim, Han Gyeol Kim, and Seung Hyeun Lee report a striking drug response in advanced lung cancer in a 2026 case. Their patient was a 52-year-old man with a rare EGFR mutation and cancer spread to liver and brain. Three prior treatment lines had failed in turn.
Doctors then gave amivantamab with chemotherapy as a fourth-line salvage plan. Scans soon showed the lung mass and the liver and brain spots shrinking hard. Fluid in his belly cleared, and his strength slowly returned. The response has held beyond nine months with only mild rash and mouth sores. The case is the first of its kind for this mutation.
Catalog record
| CREATOR | Jiwon Kim, Han Gyeol Kim, Seung Hyeun Lee |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |