Comparative risk of arrhythmias associated with systemic antifungal agents: a disproportionality analysis of the FAERS database
Xiaohu Yang, Hao Li, Kai Liu, Lingti Kong · 2026
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Description
Xiaohu Yang and co-authors scan a United States safety database for heart rhythm risks from antifungal drugs in 2026. Systemic antifungals save lives in deep infections, yet some may disturb the heart's electrical timing. Real-world reports offer a wide lens on that risk.
The team mined 42,393 reports with four statistical screens for lopsided reporting. Itraconazole, fluconazole, and posaconazole drew the strongest rhythm signals across the checks. Fluconazole stood out for fast rhythms and a dangerous twisting rhythm pattern. Three other drugs showed no signal on any screen. The authors advise matching drug choice to each patient's heart risk and current medicines.
Catalog record
| CREATOR | Xiaohu Yang, Hao Li, Kai Liu, Lingti Kong |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |