miR-181a-5p of MSCs-derived exosomes promote vascular formation and cell proliferation by PTEN/PI3K/AKT axis in HUVECs
Wenxin Shi, Qian Li, Xiaoli Dong, Yanfang Du, Yanlong Fu, Xianghua Huang, Zhongkang Li · 2026
Read miR-181a-5p of MSCs-derived exosomes promote vascular formation and cell proliferation by PTEN/PI3K/AKT axis in HUVECs by Wenxin Shi, Qian Li, Xiaoli Dong, Yanfang Du, Yanlong Fu, Xianghua Huang, Zhongkang Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13247093.txt.
Description
Wenxin Shi and co-authors trace how a tiny RNA carried in stem-cell parcels helps new blood vessels grow. The group's earlier work showed such parcels, called exosomes, aid vaginal tissue repair in rats. Here they study parcels from human cord stem cells fed to vessel-lining cells in dishes, and zoom in on one RNA cargo, miR-181a-5p.
The RNA was shown to bind and quiet a brake gene, PTEN, which loosens a growth pathway inside the cells. With the RNA active, the vessel cells multiplied, migrated, and formed tubes more readily; forcing the brake gene back on partly undid the effect. The authors frame the RNA-brake pair as the mechanism behind the parcels' repair power.
Catalog record
| CREATOR | Wenxin Shi, Qian Li, Xiaoli Dong, Yanfang Du, Yanlong Fu, Xianghua Huang, Zhongkang Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |