Bioactive secretory leukocyte protease inhibitor (SLPI)-derived short peptides (SDSPs) attenuate LPS-induced inflammatory responses in macrophages
Wattanased Jarisarapurin, Khwandow Kunchana, Onnicha Srisopar, Kitiyarat Bunsoong, Sittiruk Roytrakul, Sarawut Kumphune · 2026
Read Bioactive secretory leukocyte protease inhibitor (SLPI)-derived short peptides (SDSPs) attenuate LPS-induced inflammatory responses in macrophages by Wattanased Jarisarapurin, Khwandow Kunchana, Onnicha Srisopar, Kitiyarat Bunsoong, Sittiruk Roytrakul, Sarawut Kumphune (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13247068.txt.
Description
Wattanased Jarisarapurin and co-authors cut a calming protein into short peptides in a 2026 study. The protein, SLPI, damps inflammation but breaks down fast and enters cells poorly. Short peptides are small, potent, and gentle on the immune system, so they may carry its power better. The team simulated digestion of the protein by two enzymes, in the computer.
The cuts yielded twenty fragments plus the protein's head piece. Some fragments scored as likely anti-inflammatory. In mouse immune cells inflamed by a bacterial toxin, four fragments stood out. They cut excess reactive oxygen and quieted a core inflammation pathway, much like the whole protein. The cell results matched the computer predictions. The authors name the four as candidates for new anti-inflammatory drugs. They call for animal and clinical trials to follow.
Catalog record
| CREATOR | Wattanased Jarisarapurin, Khwandow Kunchana, Onnicha Srisopar, Kitiyarat Bunsoong, Sittiruk Roytrakul, Sarawut Kumphune |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |