Premenopausal bilateral oophorectomy leads to steeper declines in gray matter volume and alterations in perfusion and brain bioenergetics
Lisa Mosconi, Matilde Nerattini, Yelena Havryliuk, Caroline Andy, Francesca Fauci, Camila Boneu, Trisha Ajila, Michael Battista, Silky Pahlajani, Jonathan P Dyke, Schantel Williams, Roberta Diaz Brinton · 2026
Read Premenopausal bilateral oophorectomy leads to steeper declines in gray matter volume and alterations in perfusion and brain bioenergetics by Lisa Mosconi, Matilde Nerattini, Yelena Havryliuk, Caroline Andy, Francesca Fauci, Camila Boneu, Trisha Ajila, Michael Battista, Silky Pahlajani, Jonathan P Dyke, Schantel Williams, Roberta Diaz Brinton (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13247055.txt.
Description
Lisa Mosconi and eleven co-authors track brain changes after early ovary removal, in a 2026 study. Removing both ovaries before menopause ends hormone production abruptly and has been tied to higher neurological risk later. The team scanned women before and after surgery with several MRI methods, comparing them with matched women who kept their ovaries.
The surgery group lost volume faster in memory regions and in white matter, and blood flow rose faster in a frontal region. Their pituitary hormones also climbed more steeply, and those climbs tracked with shrinkage in related brain areas and altered flow near the memory regions. The authors stress the study is exploratory and meant to size the effects for larger, longer work, but it gives the first direct evidence that the surgery bends brain aging.
Catalog record
| CREATOR | Lisa Mosconi, Matilde Nerattini, Yelena Havryliuk, Caroline Andy, Francesca Fauci, Camila Boneu, Trisha Ajila, Michael Battista, Silky Pahlajani, Jonathan P Dyke, Schantel Williams, Roberta Diaz Brinton |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |