177Lutetium-PSMA-I&T therapy for metastatic castration-resistant prostate cancer (mCRPC): the first multicenter real-world study of 177Lu-PSMA-I&T in Brazil
Helena F Bruzzi, Gabriela C K Lopes, Hannah B V Bekierman, Sergio Altino de Almeida, José Alexandre Pedrosa, Camila Mosci, Haonne S Abboud, Christiane Magalhães, Isabella Palazzio, Laura Fernandes, Vinicius Freire da Silva, Juliana Tarouquella da Silva Andrade, Daniel Herchenhorn · 2026
Read 177Lutetium-PSMA-I&T therapy for metastatic castration-resistant prostate cancer (mCRPC): the first multicenter real-world study of 177Lu-PSMA-I&T in Brazil by Helena F Bruzzi, Gabriela C K Lopes, Hannah B V Bekierman, Sergio Altino de Almeida, José Alexandre Pedrosa, Camila Mosci, Haonne S Abboud, Christiane Magalhães, Isabella Palazzio, Laura Fernandes, Vinicius Freire da Silva, Juliana Tarouquella da Silva Andrade, Daniel Herchenhorn (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13246990.txt.
Description
Bruzzi and colleagues report the first multicenter real-world results for a radioactive prostate cancer therapy in Brazil, in this 2026 EJNMMI Reports study. The treatment delivers lutetium-177 attached to a molecule that homes to prostate cancer cells. It was given to forty-three heavily pretreated men whose metastatic cancer no longer answered hormone-blocking drugs, at two large oncology centers.
The prostate-specific antigen level halved in about forty-four percent of patients, a response rate resembling the approved cousin drug's trial results despite this group's heavier prior treatment. Median survival was about fourteen months. Men with cancer spread to internal organs responded less often, and the authors say that subgroup needs stronger combination approaches. The study supports the therapy's value outside clinical trials.
Catalog record
| CREATOR | Helena F Bruzzi, Gabriela C K Lopes, Hannah B V Bekierman, Sergio Altino de Almeida, José Alexandre Pedrosa, Camila Mosci, Haonne S Abboud, Christiane Magalhães, Isabella Palazzio, Laura Fernandes, Vinicius Freire da Silva, Juliana Tarouquella da Silva Andrade, Daniel Herchenhorn |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |