Algorithm-based quantification of tissue vascularization in immunohistochemical stainings of tissue sections
Ario Dastmaltschi, Tarik Bozoglu, Vijayanand Rajendran, Seyed Amir Shakouri, Shriyam Bhardwaz, Denise Messerer, Simone Renner, Andrea Bähr, Eckhard Wolf, Tobias Weinberger, Hendrik B. Sager, Karl-Ludwig Laugwitz, Christian Kupatt, Tilman Ziegler · 2026
Read Algorithm-based quantification of tissue vascularization in immunohistochemical stainings of tissue sections by Ario Dastmaltschi, Tarik Bozoglu, Vijayanand Rajendran, Seyed Amir Shakouri, Shriyam Bhardwaz, Denise Messerer, Simone Renner, Andrea Bähr, Eckhard Wolf, Tobias Weinberger, Hendrik B. Sager, Karl-Ludwig Laugwitz, Christian Kupatt, Tilman Ziegler (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13246862.txt.
Description
Dastmaltschi and co-authors built software to count blood vessels and their helper cells in microscope images, in this 2026 Scientific Reports paper. Capillaries are wrapped by pericytes, and measuring both in stained tissue slices is normally done by eye, which makes results vary between examiners and laboratories. Their tool, called CAPPER, automates the counting with adaptive thresholds and shape analysis.
The software quantified capillary density and pericyte coverage reliably across brain, heart, muscle, and kidney tissue, in mice and pigs, and in several disease states. The team also proposes a panel of markers to pin down pericytes, a cell type whose identity markers are notoriously unreliable. Standardized counting, they argue, will make vascular studies comparable across research groups.
Catalog record
| CREATOR | Ario Dastmaltschi, Tarik Bozoglu, Vijayanand Rajendran, Seyed Amir Shakouri, Shriyam Bhardwaz, Denise Messerer, Simone Renner, Andrea Bähr, Eckhard Wolf, Tobias Weinberger, Hendrik B. Sager, Karl-Ludwig Laugwitz, Christian Kupatt, Tilman Ziegler |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |