Biphasic regulation of myogenesis by ALDH2, aldosterone, and oxidative stress
José Emmanuel Martínez-Cortés, Maikel Valle-Clara, Damaso Fernández-Hernández, Guillermo Ávila · 2026
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Description
Martínez-Cortés and co-authors studied how oxidative stress shapes muscle building in this 2026 Pflügers Archiv paper. Muscle forms when precursor cells fuse into fibers, and the process is sensitive to reactive oxygen species. The team focused on ALDH2, a mitochondrial enzyme that detoxifies a harmful fat-oxidation product, and on aldosterone, a hormone that raises oxidative stress, using mouse muscle cells in culture.
Raising oxidative stress, whether with peroxide, aldosterone, or drugs blocking ALDH2, produced a two-phase effect: fusion was suppressed in the first days, then stimulated later. Drugs that activate ALDH2 prevented both the stress and the odd timing. The authors trace the early and late phases to different signaling helpers, calpain first and a p38 pathway later.
Catalog record
| CREATOR | José Emmanuel Martínez-Cortés, Maikel Valle-Clara, Damaso Fernández-Hernández, Guillermo Ávila |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |