SLC30A10 downregulation is associated with cGAS-STING pathway activation in colorectal tubular adenoma
Tongshuo Qu, Guoju Jin, Liping Zhang, Tangyou Mao, Yupu Yao, Runhua Chen · 2026
Read SLC30A10 downregulation is associated with cGAS-STING pathway activation in colorectal tubular adenoma by Tongshuo Qu, Guoju Jin, Liping Zhang, Tangyou Mao, Yupu Yao, Runhua Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13246812.txt.
Description
Benign polyps in the colon can be a first step toward cancer, and Qu and co-authors compare the proteins of such polyps with matched healthy lining from fifteen patients. A mass-spectrometry scan shows one protein sharply reduced in the polyps: SLC30A10, a manganese exporter. The tissue also held more manganese, as direct element measurement confirmed.
At the same time, an immune alarm pathway, cGAS-STING, ran hotter in the polyp tissue, along with a growth-linked protein that shared space in the nucleus with one of the pathway's signals. The authors propose that losing the exporter lets manganese build up and stirs the alarm, possibly feeding polyp growth. They flag the link for deeper study.
Catalog record
| CREATOR | Tongshuo Qu, Guoju Jin, Liping Zhang, Tangyou Mao, Yupu Yao, Runhua Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 69 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |