Luteolin and neuroinflammation: a multi-target therapeutic strategy for central nervous system disorders
Jianting Huang, Miaomiao Yu, Yanan Zou, Lezhen Wang, Yuan Ma, Yue Ma, Xiangyi Kong, Fei Rong · 2026
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Description
Jianting Huang and co-authors review luteolin, a plant compound, as a multi-target guard against brain inflammation in 2026. Inflammation inside the brain drives many disorders of the central nervous system. Luteolin occurs in herbs, fruits, and vegetables and shows wide protective effects in lab models.
The review explains how the compound calms overactive microglia, the brain's immune cells. It also tunes several signal paths and boosts the cell's own antioxidant defenses. Together these actions cut inflammatory output, shield neurons from oxidative harm, and slow cell death. Two hurdles block clinical use: poor absorption by mouth and weak entry into the brain. The authors map where formulation work should focus next.
Catalog record
| CREATOR | Jianting Huang, Miaomiao Yu, Yanan Zou, Lezhen Wang, Yuan Ma, Yue Ma, Xiangyi Kong, Fei Rong |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |