RNP interfaces as regulatory “active sites”: a repurposing strategy for small molecules targeting viral 5′-untranslated regions
Louis G. Smith, Solomon Attionu, Sudeshi M. Abedeera, Barrington Henry, Srinivasa Penumutchu, Blanton S. Tolbert · 2026
Read RNP interfaces as regulatory “active sites”: a repurposing strategy for small molecules targeting viral 5′-untranslated regions by Louis G. Smith, Solomon Attionu, Sudeshi M. Abedeera, Barrington Henry, Srinivasa Penumutchu, Blanton S. Tolbert (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13246389.txt.
Description
Louis G Smith and co-authors propose a drug hunting strategy aimed at RNA-protein junctions in a 2026 Perspective. Such junctions steer gene activity and help viruses copy themselves. Few small drugs are known to work at these junctions, partly because they lack the neat pockets drug hunters favor.
The authors argue the junctions act as the true working sites of regulatory RNA. Their plan joins shape prediction, motion simulation, and screening of approved drugs for new uses. Virus control regions offer a test bed, since their junctions are shared and vital. A worked sketch uses a hand-foot-and-mouth virus region to show the steps. The framework could generalize to many RNA targets.
Catalog record
| CREATOR | Louis G. Smith, Solomon Attionu, Sudeshi M. Abedeera, Barrington Henry, Srinivasa Penumutchu, Blanton S. Tolbert |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |