Sofpironium Bromide for the Treatment of Primary Axillary Hyperhidrosis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Devanie Martani, Milena S Silva, Luciana Nakanishi, Laís F Valente, Georgina G Garza-Dueñas, Meire O Silva, Elisete I Crocco · 2026
Read Sofpironium Bromide for the Treatment of Primary Axillary Hyperhidrosis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Devanie Martani, Milena S Silva, Luciana Nakanishi, Laís F Valente, Georgina G Garza-Dueñas, Meire O Silva, Elisete I Crocco (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13246317.txt.
Description
Devanie Martani and co-authors pooled trials of a skin drug for heavy underarm sweating in a 2026 review. The drug, sofpironium bromide, is a topical treatment built to act locally and limit effects across the body. Past trials existed, but their results had not been pooled in numbers. The team searched four databases for trials that compared the drug with a plain vehicle cream.
Five trials with close to fourteen hundred patients were included, and over half got the drug. Sweat weight at the end of treatment was much lower on the drug than on the vehicle. Patients on the drug were also far more likely to gain a clear improvement on a standard severity scale. Yet dropouts due to side effects were more common on the drug, and skin irritation and pain at the site were more frequent. The review weighs that trade off for patients and clinicians.
Catalog record
| CREATOR | Devanie Martani, Milena S Silva, Luciana Nakanishi, Laís F Valente, Georgina G Garza-Dueñas, Meire O Silva, Elisete I Crocco |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |