Acute Severe Pancolitis After Initiation of a Calcitonin Gene-Related Peptide Receptor Antagonist: A Case Report
Abhimati Ravikulan, James Falvey, Jan Kubovy · 2026
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Description
Ravikulan, Falvey, and Kubovy report a serious drug reaction in this 2026 ACG Case Reports Journal article. A fifty-year-old woman whose ulcerative colitis had been limited and well controlled started atogepant, a newer migraine-prevention drug that blocks the CGRP receptor. Soon afterward she developed abdominal pain and diarrhea, and scans and scope examinations showed severe inflammation across her whole colon.
Steroids given by vein failed to settle the flare. She recovered only after the migraine drug was stopped and she received infliximab, an immune-suppressing infusion, and she remained well three months later. The authors warn clinicians to use this drug class carefully in patients with inflammatory bowel disease.
Catalog record
| CREATOR | Abhimati Ravikulan, James Falvey, Jan Kubovy |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 10 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |