Expression of melanoma differentiation–associated gene 5 in the epidermis and cutaneous deposition of complement C3 and immunoglobulins in patients with dermatomyositis
Yoshiaki Zaizen, Takuma Koga, Masahiro Tsutsumi, Shinjiro Kaieda, Jun Akiba, Takekuni Nakama, Tomoaki Hoshino, Seth Domfeh, Seth Domfeh, Seth Domfeh · 2026
Read Expression of melanoma differentiation–associated gene 5 in the epidermis and cutaneous deposition of complement C3 and immunoglobulins in patients with dermatomyositis by Yoshiaki Zaizen, Takuma Koga, Masahiro Tsutsumi, Shinjiro Kaieda, Jun Akiba, Takekuni Nakama, Tomoaki Hoshino, Seth Domfeh, Seth Domfeh, Seth Domfeh (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13245797.txt.
Description
Zaizen, Koga, and Tsutsumi studied skin biopsies from patients with dermatomyositis, an autoimmune disease that attacks muscle and skin, in this 2026 PLOS One paper. They stained samples from twenty-two patients and thirteen controls to map where complement proteins, antibodies, and a viral-sensor protein called MDA5 sit in the skin layers.
Patient skin carried clearly more complement C3c and two antibody types, IgM and IgA, in the upper dermis where the inflammation occurs, a pattern pointing to immune-complex injury. MDA5 appeared in the outer skin of everyone, but in patients it also showed up strongly in inflammatory cells and tiny blood vessels deeper in the skin. The map helps explain how the skin damage develops.
Catalog record
| CREATOR | Yoshiaki Zaizen, Takuma Koga, Masahiro Tsutsumi, Shinjiro Kaieda, Jun Akiba, Takekuni Nakama, Tomoaki Hoshino, Seth Domfeh, Seth Domfeh, Seth Domfeh |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |