Spectrofluorimetric quantification of terconazole in pharmaceutical creams with comprehensive sustainability evaluation
Huda Salem AlSalem, Sara Naif Alharbi, Shimaa A Mahmoud, Noha S Katamesh, Mohamed A Abdel-Lateef · 2026
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Description
Huda Salem AlSalem and co-authors built a glow-based test for measuring the antifungal terconazole in creams. Their methods paper appeared in BMC Chemistry in 2026. The trick is quenching: terconazole binds the dye eosin Y into a non-fluorescent complex, dimming the dye's glow in exact proportion to how much drug is present. The team mapped the chemistry behind the dimming and tuned the conditions.
The signal tracked drug concentration linearly across a sub-microgram working range, with detection limits lower still. Validated under international ICH guidelines, the assay returned respectable recoveries when applied to commercial vaginal cream products. Five scoring tools also rated the method green and practical. Their pitch is a cheap, sensitive quality-control test for a widely used antifungal, built from a common dye and a fluorimeter rather than costly chromatography. Pharmacies and small manufacturers are the natural audience.
Catalog record
| CREATOR | Huda Salem AlSalem, Sara Naif Alharbi, Shimaa A Mahmoud, Noha S Katamesh, Mohamed A Abdel-Lateef |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |