Advancement of humanized mice and leading applications in immunological disease models
Satoru Munakata, Yuki Imura, Sota Fujimori, Ryota Sato, Piruzyan Mariam, Yuzo Koda · 2026
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Description
Satoru Munakata and co-authors survey how mice carrying human immune systems have become central tools for studying immune disease. Their review appeared in Inflammation and Regeneration in 2026. Humanized mice are immune-deficient animals engrafted with human immune cells, liver cells, or thymus tissue, building an approximation of human immunity that ordinary lab mice cannot offer. The review traces progress in rebuilding a diverse human immune system inside the mouse.
Recent work layers in patient-specific elements, such as the self-attacking antibodies and T cells behind autoimmune disease, and pairs the animals with single-cell analyses of human tissue. Applications span modeling autoimmune conditions, testing drug candidates, and probing why therapies fail. The authors call these models foundational for both research and drug discovery. Their caveats are practical: reconstitution is still incomplete and variable. The trajectory, though, is toward models that fail less often for mouse-specific reasons.
Catalog record
| CREATOR | Satoru Munakata, Yuki Imura, Sota Fujimori, Ryota Sato, Piruzyan Mariam, Yuzo Koda |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 104 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |