Crosstalk between iron metabolism dysregulation and the oral microbiome in periodontitis
Zhenyuan Yu, Shuwei Zhang, Ze Lu, Hongyan Wang, Haijie Liu, Yuchao Li, Yaping Pan · 2026
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Description
Zhenyuan Yu, Shuwei Zhang, and Ze Lu reviewed the two-way traffic between iron and mouth bacteria in gum disease. Their narrative review appeared in the Journal of Oral Microbiology in 2026. Periodontitis is driven by oral pathogens, yet it also tracks with body-wide disease. Iron sits at the crossroads: too much free iron feeds radical damage and a form of cell death called ferroptosis.
In periodontitis, blood iron and its carrier transferrin fall while storage and control proteins rise, a signature of iron locked away by inflammation. That misdistribution shelters pathogens, fans inflammation, kills ligament cells by ferroptosis, and eats into jaw bone. The same iron disorder ties gum disease to anemia and other systemic conditions. Chelating or rebalancing iron looks promising as therapy, the authors say, but solid clinical trials are still missing. The review frames gums as an iron story, not only a plaque story.
Catalog record
| CREATOR | Zhenyuan Yu, Shuwei Zhang, Ze Lu, Hongyan Wang, Haijie Liu, Yuchao Li, Yaping Pan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |