TRAP1 ablation improves mitochondrial cristae and oxidative phosphorylation in pancreatic cancer stem cells
Giulia Ambrosini, Elisa Dalla Pozza, Ilaria Cristanini, Sara Vinco, Enrica Cappellozza, Barbara Cisterna, Claudio Laquatra, Andrea Rasola, Emanuela Bottani, Ilaria Dando · 2026
Read TRAP1 ablation improves mitochondrial cristae and oxidative phosphorylation in pancreatic cancer stem cells by Giulia Ambrosini, Elisa Dalla Pozza, Ilaria Cristanini, Sara Vinco, Enrica Cappellozza, Barbara Cisterna, Claudio Laquatra, Andrea Rasola, Emanuela Bottani, Ilaria Dando (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13244268.txt.
Description
Ambrosini and co-authors remove a mitochondrial helper in pancreatic cancer stem cells. The helper, TRAP1, rose after two weeks of stem cell culture. Its rise matched a shift toward sugar-based energy. Cells without TRAP1 formed looser spheres than parent cells. Core stem traits like slow growth and drug resistance stayed.
Loss of TRAP1 raised the adhesion gene CDH1. Adding succinate reversed that rise, naming a control axis. Mitochondria changed shape deeply without TRAP1. Parent cells held long mitochondria with wide inner folds. The work ties TRAP1 to energy mode and cell grip.
Catalog record
| CREATOR | Giulia Ambrosini, Elisa Dalla Pozza, Ilaria Cristanini, Sara Vinco, Enrica Cappellozza, Barbara Cisterna, Claudio Laquatra, Andrea Rasola, Emanuela Bottani, Ilaria Dando |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |