Integrative Proteogenomic Characterization of Left‐Sided and Right‐Sided Colorectal Cancer
An Huang, Haopeng Hong, Yonghui Sun, Zhaoya Gao, Jingxuan Xu, Jiajia Chen, Yong Yang, Zhongyi Chen, Hebing Chen, Ming Li, Xiaodong Wang, Jin Gu · 2026
Read Integrative Proteogenomic Characterization of Left‐Sided and Right‐Sided Colorectal Cancer by An Huang, Haopeng Hong, Yonghui Sun, Zhaoya Gao, Jingxuan Xu, Jiajia Chen, Yong Yang, Zhongyi Chen, Hebing Chen, Ming Li, Xiaodong Wang, Jin Gu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13243882.txt.
Description
An Huang, Haopeng Hong, and Yonghui Sun profiled colon cancers by the side of the bowel they grow on, layering genes, proteins, and protein switches. Their study appeared in MedComm in 2026. Left-sided and right-sided tumors arise from different embryonic tissue and already behave differently in the clinic. The team ran exome, protein, and phosphoprotein sequencing on eighty tumor-and-normal tissue pairs to find out why.
Left-sided cancers were driven mainly by chromosomal instability and grew dense in blood vessels. Right-sided cancers leaned on microsatellite instability instead, a scrambling caused by failed DNA repair. Their immune neighborhoods also split: right-sided tumors showed stronger antigen display by M1 macrophages. The share of repair-deficient tumors reaching instability differed by side too. The authors argue these differences explain why targeted and immune therapies land unevenly, and they offer the atlas for tailoring treatment by tumor side.
Catalog record
| CREATOR | An Huang, Haopeng Hong, Yonghui Sun, Zhaoya Gao, Jingxuan Xu, Jiajia Chen, Yong Yang, Zhongyi Chen, Hebing Chen, Ming Li, Xiaodong Wang, Jin Gu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |