Severe IL-6–dominant immune-mediated inflammatory response complicated by probable arginine vasopressin deficiency following ivonescimab-based therapy in advanced EGFR-mutant lung squamous cell carcinoma: a case report
Fang Yang, Linli Xuan, Jun Li · 2026
Read Severe IL-6–dominant immune-mediated inflammatory response complicated by probable arginine vasopressin deficiency following ivonescimab-based therapy in advanced EGFR-mutant lung squamous cell carcinoma: a case report by Fang Yang, Linli Xuan, Jun Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13243123.txt.
Description
Fang Yang and colleagues report a 2026 case of severe side effects from a new lung cancer drug. Their patient was a 72-year-old man with stage IV squamous lung cancer and an EGFR gene change. Soon after his first dose of ivonescimab with chemotherapy, he developed a lasting high fever.
Blood tests showed very high levels of IL-6, a protein that fuels inflammation, and steroid drugs calmed the fever fast. A second dose brought a worse reaction, plus heavy urine output that pointed to a hormone problem near the brain. Care with steroids and other drugs eased his symptoms over time. The team urges early hormone checks and close IL-6 tracking when fever will not settle.
Catalog record
| CREATOR | Fang Yang, Linli Xuan, Jun Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 15 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |