Comparative efficacy of exercise interventions on depressive symptoms and related outcomes in patients with Alzheimer’s disease, cognitive impairment, and Parkinson’s disease: a systematic review and network meta-analysis
Zixin Chen, YuanXi Zhang, Xiaojie Zhu, Huihong Wu, Tongwu Yu, Ziwang Liu · 2026
Read Comparative efficacy of exercise interventions on depressive symptoms and related outcomes in patients with Alzheimer’s disease, cognitive impairment, and Parkinson’s disease: a systematic review and network meta-analysis by Zixin Chen, YuanXi Zhang, Xiaojie Zhu, Huihong Wu, Tongwu Yu, Ziwang Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13243066.txt.
Description
Zixin Chen and co-authors offer a 2026 network meta-analysis of exercise for low mood in Alzheimer disease, cognitive impairment, and Parkinson disease. Depression is common across these brain conditions and worsens care. Twenty-three randomized trials covering about sixteen hundred patients compared exercise types against control conditions.
No exercise type beat control overall for depressive symptoms in the pooled network. One secondary result stood out: cognitive exercise improved general mental test scores compared with daily activities. Motor scores in Parkinson disease showed no clear overall advantage. The authors describe the mood evidence as unstable. They counsel caution around claims for combined programs and ask for better focused trials by disease type.
Catalog record
| CREATOR | Zixin Chen, YuanXi Zhang, Xiaojie Zhu, Huihong Wu, Tongwu Yu, Ziwang Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |