Malignant Catatonia From Paliperidone Withdrawal With Successful Pharmacological Treatment: A Diagnostic and Therapeutic Challenge
Muhammad Usman, Muhammad Usman Shahbaz, Laiba Murtaza, Muhammad Zawar Asif, Mohankumar Doraiswamy · 2026
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Description
Muhammad Usman and co-authors reported this 2026 case of severe catatonia after a missed long-acting drug dose. Catatonia freezes movement and speech; its malignant form adds unstable body functions and can kill. Stopping oral antipsychotics is a known trigger, but withdrawal from long-acting injections is rarely reported. Standard rescue is electroconvulsive therapy in intensive care.
Their patient, a 43-year-old man with schizophrenia and other conditions, missed his paliperidone injection and worsened quickly. The therapy was unavailable locally and the family declined it. High-dose sedatives of the benzodiazepine class slowly brought him back instead. He left hospital on a long tapering course, and the injection resumed later as an outpatient. The case shows a drug-only path when first-line treatment cannot be used.
Catalog record
| CREATOR | Muhammad Usman, Muhammad Usman Shahbaz, Laiba Murtaza, Muhammad Zawar Asif, Mohankumar Doraiswamy |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 19 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |