Mechanisms of Traditional Chinese Medicine-Derived Alkaloids in Colorectal Cancer Therapy: Molecular Targets, Preclinical Evidence, and Translational Prospects
Lin Guo, Wei Zhao, Haoyang Wang, Shuxuan Qiu, Ruiying Wang, Jingya Zhang, Shuo Tian, Mingsan Miao · 2026
Read Mechanisms of Traditional Chinese Medicine-Derived Alkaloids in Colorectal Cancer Therapy: Molecular Targets, Preclinical Evidence, and Translational Prospects by Lin Guo, Wei Zhao, Haoyang Wang, Shuxuan Qiu, Ruiying Wang, Jingya Zhang, Shuo Tian, Mingsan Miao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13242773.txt.
Description
Lin Guo and co-authors offer a 2026 review of plant alkaloids from traditional Chinese medicine as colorectal cancer treatments. Alkaloids such as berberine, matrine, and camptothecin show anti-tumor activity across several signaling pathways at once. No single review had yet organized their combined evidence for this cancer.
The review maps how these compounds slow tumor growth, trigger cell death, block invasion, and reverse drug resistance. Key pathways include growth and survival circuits inside tumor cells. Nano-sized delivery versions receive separate attention for their ability to concentrate drug at the tumor. Limitations in current evidence are discussed openly. The authors outline structure-based design and targeted delivery as the route toward efficient, lower-toxicity therapies.
Catalog record
| CREATOR | Lin Guo, Wei Zhao, Haoyang Wang, Shuxuan Qiu, Ruiying Wang, Jingya Zhang, Shuo Tian, Mingsan Miao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 83 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |