Current Evidence of Acetyl-L-Carnitine Use in Mood Disorders-: A Systematic Review and Meta-Analysis
Rakesh Kumar, Zahra Hashempour, Sara Shahriarirad, Reza Shahriarirad, Leslie C Hassett, Balwinder Singh, Paul E Croarkin, Marin Veldic, Mark A Frye, Sandeep R Pagali · 2026
Read Current Evidence of Acetyl-L-Carnitine Use in Mood Disorders-: A Systematic Review and Meta-Analysis by Rakesh Kumar, Zahra Hashempour, Sara Shahriarirad, Reza Shahriarirad, Leslie C Hassett, Balwinder Singh, Paul E Croarkin, Marin Veldic, Mark A Frye, Sandeep R Pagali (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13242760.txt.
Description
Rakesh Kumar and a large team offer a 2026 systematic review and meta-analysis of acetyl-L-carnitine for mood disorders. Levels of this compound run low in many people with major depression, which may disturb energy handling and brain plasticity. The team gathered trials and observational studies in depression and bipolar disorder.
Fifteen studies entered the review, and ten entered the pooled analysis, covering several hundred participants. The compound reduced depressive symptoms compared with placebo and matched standard antidepressants in effect, with fewer side effects. Older adults and people with hard-to-treat depression seemed to gain most. The authors see the compound as both a possible marker and a treatment candidate. Larger, longer trials are still needed.
Catalog record
| CREATOR | Rakesh Kumar, Zahra Hashempour, Sara Shahriarirad, Reza Shahriarirad, Leslie C Hassett, Balwinder Singh, Paul E Croarkin, Marin Veldic, Mark A Frye, Sandeep R Pagali |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |