Pharmacological restoration of impaired autophagy in retinal ganglion cells prevents abnormal mitochondrial accumulation and glaucomatous neurodegeneration
Prabhavathi Maddineni, Balasankara Reddy Kaipa, Bindu Kodati, Karthikeyan Kesavan, Linya Li, J Cameron Millar, Sam Yacoub, Ramesh B. Kasetti, Abbot F. Clark, Gulab S. Zode · 2026
Read Pharmacological restoration of impaired autophagy in retinal ganglion cells prevents abnormal mitochondrial accumulation and glaucomatous neurodegeneration by Prabhavathi Maddineni, Balasankara Reddy Kaipa, Bindu Kodati, Karthikeyan Kesavan, Linya Li, J Cameron Millar, Sam Yacoub, Ramesh B. Kasetti, Abbot F. Clark, Gulab S. Zode (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13242679.txt.
Description
Prabhavathi Maddineni and co-authors study glaucoma damage in a 2026 paper on eye nerve cells. Glaucoma slowly kills the retinal ganglion cells that carry sight signals to the brain. High pressure in the eye is the main known risk, yet some patients keep losing sight even when pressure is controlled.
The team focused on autophagy, the cell's system for clearing damaged parts, including worn-out mitochondria. In two mouse models of glaucoma, they tracked markers of that system and of cell damage over time. They also tested mice lacking a key autophagy gene in these cells, and a drug, Torin 2, that boosts the clearing system. Human retina tissue was tested outside the body as well, to see whether boosting cleanup can protect the cells.
Catalog record
| CREATOR | Prabhavathi Maddineni, Balasankara Reddy Kaipa, Bindu Kodati, Karthikeyan Kesavan, Linya Li, J Cameron Millar, Sam Yacoub, Ramesh B. Kasetti, Abbot F. Clark, Gulab S. Zode |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |