Blood-based DNA methylation marker model for short-term and long-term lung cancer risk prediction
Megha Bhardwaj, Yi-Qian Sun, Clara Frick, Ben Schöttker, Oluf Dimitri Røe, Bernd Holleczek, Xiao-Mei Mai, Hermann Brenner · 2026
Read Blood-based DNA methylation marker model for short-term and long-term lung cancer risk prediction by Megha Bhardwaj, Yi-Qian Sun, Clara Frick, Ben Schöttker, Oluf Dimitri Røe, Bernd Holleczek, Xiao-Mei Mai, Hermann Brenner (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13242670.txt.
Description
Megha Bhardwaj and co-authors built a blood test model that estimates a person's future lung cancer risk from DNA methylation marks. Their paper appeared in BMC Medicine in 2026. Low-dose CT screening saves lives, but choosing exactly who benefits most remains difficult and costly. The model was trained on 2,459 participants in a German population cohort, using methylation sites already linked to lung cancer in earlier genome-wide studies.
In a separate Norwegian cohort, the model kept its accuracy for cases diagnosed up to eighteen years later and for near-term cases alike. Its discrimination scores in external testing matched the strong results from development. Because the model covers never-smokers as well as smokers, it could widen or sharpen screening eligibility beyond smoking history alone. The authors present it as a step toward a practical blood-based risk test.
Catalog record
| CREATOR | Megha Bhardwaj, Yi-Qian Sun, Clara Frick, Ben Schöttker, Oluf Dimitri Røe, Bernd Holleczek, Xiao-Mei Mai, Hermann Brenner |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |