Lamin B1 safeguards the B cell genome and shapes lymphoma outcome
Filip Filipsky, Katarina B. Chapman, Johannes Bloehdorn, Oscar Maiques, Abigail Lee, Andrew Clear, Jun Wang, John Gribben, Michael Hausmann, Christoph Cremer, Andrejs Braun, Marta C. Sallan, Tanya Klymenko · 2026
Read Lamin B1 safeguards the B cell genome and shapes lymphoma outcome by Filip Filipsky, Katarina B. Chapman, Johannes Bloehdorn, Oscar Maiques, Abigail Lee, Andrew Clear, Jun Wang, John Gribben, Michael Hausmann, Christoph Cremer, Andrejs Braun, Marta C. Sallan, Tanya Klymenko (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13242629.txt.
Description
Filip Filipsky and colleagues show that a nuclear scaffold protein quietly protects B cells from DNA damage. Their study appeared in HemaSphere in 2026. Lamin B1 lines the inside of the nucleus and helps organize the genome, but germinal center B cells dial it down while they deliberately mutate their antibody genes. The team built mouse and cell models with reduced Lamin B1 and mapped where DNA breaks appeared.
Cells short on Lamin B1 carried extra DNA damage and scrambled gene activity. Break mapping found hotspots that were not random: they clustered near gene start sites and near control regions governing protein production. In patients, low Lamin B1 levels in diffuse large B-cell lymphoma tracked with worse outcomes. The protein thus looks like a guardian of exactly the genome regions B cells can least afford to break. Its loss may help explain how some lymphomas arise and progress.
Catalog record
| CREATOR | Filip Filipsky, Katarina B. Chapman, Johannes Bloehdorn, Oscar Maiques, Abigail Lee, Andrew Clear, Jun Wang, John Gribben, Michael Hausmann, Christoph Cremer, Andrejs Braun, Marta C. Sallan, Tanya Klymenko |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 73 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |