Obinutuzumab, lenalidomide, and venetoclax for the initial treatment of patients with advanced‐stage follicular lymphoma: Results of the Phase Ib/II LEVERAGE study
Chan Y. Cheah, Piers Blombery, Amanda Johnston, Joel Wight, Katharine L. Lewis, Rory Bennett, Jing Xie, Stella Vlachos, Sally M. Hunter, Joyce Gonzales, Sally Binks, John F. Seymour · 2026
Read Obinutuzumab, lenalidomide, and venetoclax for the initial treatment of patients with advanced‐stage follicular lymphoma: Results of the Phase Ib/II LEVERAGE study by Chan Y. Cheah, Piers Blombery, Amanda Johnston, Joel Wight, Katharine L. Lewis, Rory Bennett, Jing Xie, Stella Vlachos, Sally M. Hunter, Joyce Gonzales, Sally Binks, John F. Seymour (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13242628.txt.
Description
Chan Cheah and co-authors ran an early-phase trial of a chemotherapy-free triplet for newly diagnosed, advanced follicular lymphoma. Their study appeared in HemaSphere in 2026. Fifty patients with high tumor burden received obinutuzumab, lenalidomide, and venetoclax in six induction cycles, with venetoclax dose levels tested along the way. Responders then moved to two years of maintenance antibody, and blood-based tumor DNA was tracked for residual disease.
Complete responses came in at eighty-six percent, and nearly all patients responded at least partly. Two years out, almost all patients were alive and free of progression in this follow-up window. Low white cell counts, diarrhea, and chest infections were the most common side effects. Clearing tumor DNA after just one cycle predicted a very high chance of staying negative. The authors present the regimen as a strong chemotherapy-free candidate now ready for larger comparison trials.
Catalog record
| CREATOR | Chan Y. Cheah, Piers Blombery, Amanda Johnston, Joel Wight, Katharine L. Lewis, Rory Bennett, Jing Xie, Stella Vlachos, Sally M. Hunter, Joyce Gonzales, Sally Binks, John F. Seymour |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |