Prophylactic Administration of Gypsophila oldhamiana Extract Restricts Acute Toxoplasma gondii Infection via the DC-IL-12-CD8⁺ T Cell Axis in a Murine Model
Pureum Sun, Yeeun Kim, Juyoung Kim, In Soo Kim, Jaeyul Kwon, Winifrida Kidima, Jinki Yeom, Suyoung Choi, Bo-In Kwon · 2026
Read Prophylactic Administration of Gypsophila oldhamiana Extract Restricts Acute Toxoplasma gondii Infection via the DC-IL-12-CD8⁺ T Cell Axis in a Murine Model by Pureum Sun, Yeeun Kim, Juyoung Kim, In Soo Kim, Jaeyul Kwon, Winifrida Kidima, Jinki Yeom, Suyoung Choi, Bo-In Kwon (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13242423.txt.
Description
Pureum Sun and co-authors asked whether extracts from three traditional herbs could help mice resist Toxoplasma gondii, a widespread parasite. Their paper appeared in Acta Parasitologica in 2026. One extract came from Gypsophila oldhamiana, a plant long used in herbal medicine. Mice received the extracts by mouth before and after infection, and the team tracked parasite loads and immune responses in the spleen.
Only the Gypsophila extract clearly limited the infection, leaving treated mice with far fewer parasites than the other groups. It pushed dendritic cells to mature and release interleukin-12, which in turn expanded killer T cells that produce interferon-gamma. At the same time it raised checkpoint proteins that keep the response from overshooting. The authors present the plant as a preventive candidate worth further study.
Catalog record
| CREATOR | Pureum Sun, Yeeun Kim, Juyoung Kim, In Soo Kim, Jaeyul Kwon, Winifrida Kidima, Jinki Yeom, Suyoung Choi, Bo-In Kwon |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |