miR-125b Mediates Tau-induced Mitochondrial Dysfunction in a Cellular Model of Alzheimer’s Disease
Laura De Plano, Alessandra Saitta, Aurelio Minuti, Claudia Muscarà, Irene Gasparo, Laura Licitri, Emanuele L. Sciuto, Sabrina Conoci, Giovanni Schepici, Antonella Caccamo, Francesca Polito, Salvatore Oddo, M.’hammed Aguennouz · 2026
Read miR-125b Mediates Tau-induced Mitochondrial Dysfunction in a Cellular Model of Alzheimer’s Disease by Laura De Plano, Alessandra Saitta, Aurelio Minuti, Claudia Muscarà, Irene Gasparo, Laura Licitri, Emanuele L. Sciuto, Sabrina Conoci, Giovanni Schepici, Antonella Caccamo, Francesca Polito, Salvatore Oddo, M.’hammed Aguennouz (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13242396.txt.
Description
De Plano's team in Messina traced Alzheimer's tau harm to a tiny RNA strangling mitochondria. Lab nerve cells made to overproduce mutant tau P301L formed the model. The cells grew in dishes in the lab. The microRNA miR-125b rose sharply in the tau-laden cells. Its likely gene targets clustered heavily in mitochondrial pathways.
Gene copies for breathing-chain parts one, four, and five fell sharply. Seahorse flux tests confirmed sagging basal breathing and ATP output. Spare breathing capacity shrank too. The team names miR-125b as the bridge between tau harm and energy failure.
Catalog record
| CREATOR | Laura De Plano, Alessandra Saitta, Aurelio Minuti, Claudia Muscarà, Irene Gasparo, Laura Licitri, Emanuele L. Sciuto, Sabrina Conoci, Giovanni Schepici, Antonella Caccamo, Francesca Polito, Salvatore Oddo, M.’hammed Aguennouz |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |