Association Between Long-Term ACEI/ARB Use and Postoperative Pain in Hypertensive Patients: A Retrospective Cohort Study and Genetic Validation [Response to Letter]
Xinrui Li, Lu Che, Le Shen · 2026
Read Association Between Long-Term ACEI/ARB Use and Postoperative Pain in Hypertensive Patients: A Retrospective Cohort Study and Genetic Validation [Response to Letter] by Xinrui Li, Lu Che, Le Shen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13242200.txt.
Description
Xinrui Li, Lu Che, and Le Shen publish a 2026 response to a letter about their study linking long-term blood pressure drugs to pain after surgery. Commentators had raised several concerns about balance between groups, effect size, and interpretation. The reply walks through each point.
The authors acknowledge a leftover imbalance in a health status score and describe the two-step adjustment they used against it. They agree the effect sits below the smallest size their study was designed to detect, so the work is hypothesis-generating only. A misprinted confidence interval is corrected in the reply. They also clarify that genetic evidence used chronic pain as a stand-in because large acute pain datasets do not exist. Larger prospective studies are needed, they conclude.
Catalog record
| CREATOR | Xinrui Li, Lu Che, Le Shen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |