Inhibition of PKCγ phosphorylation protects against cerebral ischemia-reperfusion injury
Chenchen Li, Jinlun Chen, Xiangbin Ouyang, Ruijia Duan, Yijin Kuang, Yaohui He, Jieqiong Tan, Liuwang Zeng · 2026
Read Inhibition of PKCγ phosphorylation protects against cerebral ischemia-reperfusion injury by Chenchen Li, Jinlun Chen, Xiangbin Ouyang, Ruijia Duan, Yijin Kuang, Yaohui He, Jieqiong Tan, Liuwang Zeng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13242023.txt.
Description
Chenchen Li and co-authors report a 2026 study of a protein modification that worsens brain injury when blood flow returns after stroke. The protein, PKCγ, gains a phosphate tag at one specific site following the injury. A small share of the tagged protein moves into mitochondria, the cell energy centers.
Versions of the protein that mimic the tagged state suppressed a protective gene switch, raised harmful oxygen species, and pushed neurons toward death. A version that cannot be tagged did the opposite. Silencing the protein in mice shrank damaged brain areas and improved movement outcomes. The authors propose blocking this single tagging site as a stroke treatment strategy.
Catalog record
| CREATOR | Chenchen Li, Jinlun Chen, Xiangbin Ouyang, Ruijia Duan, Yijin Kuang, Yaohui He, Jieqiong Tan, Liuwang Zeng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 79 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |