Comparative efficacy and safety of bupivacaine versus articaine in third molar surgery: a systematic review and meta-analysis of randomized controlled trials
Zhimei Zeng, Linlin Wang, Guanfu Ding, Zijun Zeng · 2026
Read Comparative efficacy and safety of bupivacaine versus articaine in third molar surgery: a systematic review and meta-analysis of randomized controlled trials by Zhimei Zeng, Linlin Wang, Guanfu Ding, Zijun Zeng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13241955.txt.
Description
Zhimei Zeng and co-authors publish a 2026 systematic review and meta-analysis comparing two local anesthetics for wisdom tooth surgery. Bupivacaine and articaine are both common choices, with different speed and duration profiles. The authors searched four databases for randomized trials that compared them head to head.
Eleven trials covering several hundred patients entered the pooled analysis. Bupivacaine gave lower pain scores after surgery at several time points, with the largest gap a few hours after the procedure. Articaine started working faster. Pain during surgery, difficulty, operating time, and blood pressure measures were similar between the drugs. The authors suggest bupivacaine for longer pain relief and articaine when a quick start matters most.
Catalog record
| CREATOR | Zhimei Zeng, Linlin Wang, Guanfu Ding, Zijun Zeng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |