Impaired Lung BCAA Metabolism Promotes Ferroptosis and Resultant Pulmonary Arterial Hypertension-Associated Hepatopathy
Madelyn J Blake, Jason Hong, Adam Brownstein, Christopher J Rhodes, Emilia M Swietlik, Jeffrey C Blake, Ryan A Moon, Lynn M Hartweck, Jenna B Mendelson, Sasha Z Prisco, Todd Markowski, LeeAnn Higgins, Kevin Murray, Candance Guerrero, Sandra Breuils-Bonnet, Steeve Provencher, Joanna Pepke-Zaba, Mark · 2026
Read Impaired Lung BCAA Metabolism Promotes Ferroptosis and Resultant Pulmonary Arterial Hypertension-Associated Hepatopathy by Madelyn J Blake, Jason Hong, Adam Brownstein, Christopher J Rhodes, Emilia M Swietlik, Jeffrey C Blake, Ryan A Moon, Lynn M Hartweck, Jenna B Mendelson, Sasha Z Prisco, Todd Markowski, LeeAnn Higgins, Kevin Murray, Candance Guerrero, Sandra Breuils-Bonnet, Steeve Provencher, Joanna Pepke-Zaba, Mark (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13241934.txt.
Description
Madelyn J Blake and a large team present a 2026 study of amino acid handling in pulmonary arterial hypertension, a disease of high pressure in lung arteries. The three branched-chain amino acids are building blocks whose breakdown is disturbed in several heart and vessel diseases. Their role in this condition, and in related liver damage, was unsettled.
The authors set out the case that faulty breakdown products can switch on stress programs inside lung vessel cells. Breakdown failure also connects to ferroptosis, an iron-driven form of cell death already implicated in this disease. Prior work in brain and kidney models shows that boosting amino acid burning can limit that cell death. The study frames lung amino acid metabolism as a lever worth testing for treatment.
Catalog record
| CREATOR | Madelyn J Blake, Jason Hong, Adam Brownstein, Christopher J Rhodes, Emilia M Swietlik, Jeffrey C Blake, Ryan A Moon, Lynn M Hartweck, Jenna B Mendelson, Sasha Z Prisco, Todd Markowski, LeeAnn Higgins, Kevin Murray, Candance Guerrero, Sandra Breuils-Bonnet, Steeve Provencher, Joanna Pepke-Zaba, Mark |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |