A DPEP1-Binding and mitochondria-targeted nanocomposite relieves acute respiratory distress syndrome by inhibiting Drp1-mediated mitochondria fission
Ming He, Peng Zhang, Suya Bao, Rui Luo, Li Chen, Wenqi Huang, Weixi Jiang, An Zhang · 2026
Read A DPEP1-Binding and mitochondria-targeted nanocomposite relieves acute respiratory distress syndrome by inhibiting Drp1-mediated mitochondria fission by Ming He, Peng Zhang, Suya Bao, Rui Luo, Li Chen, Wenqi Huang, Weixi Jiang, An Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13241870.txt.
Description
Ming He and co-authors present a 2026 nanomedicine study aimed at acute respiratory distress syndrome, a severe lung failure condition. Harmful splitting of mitochondria inside lung vessel cells drives inflammation and oxidative damage in this syndrome. Singling out that process without harming the rest of the body is difficult.
The team built nanoparticles carrying a fission-blocking drug inside a metal-based scavenger network. A surface peptide steers the particles to a protein found on inflamed lung vessels, where it also discourages damaging white cell entry. In animal models, the particles reached lung mitochondria, calmed a major inflammatory alarm system, and mopped up harmful oxygen species. The authors propose the design as a translatable strategy for severe lung inflammation.
Catalog record
| CREATOR | Ming He, Peng Zhang, Suya Bao, Rui Luo, Li Chen, Wenqi Huang, Weixi Jiang, An Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |