Achaete-Scute-Like 1a Expression Is Essential for the Generation of Correct Proportions of Neuron Subtypes in the Developing Enteric Nervous System of Zebrafish (Danio rerio)
Nastasia Popowycz, Leen Uyttebroek, Jean-Pierre Timmermans, Luc Van Nassauw · 2026
Read Achaete-Scute-Like 1a Expression Is Essential for the Generation of Correct Proportions of Neuron Subtypes in the Developing Enteric Nervous System of Zebrafish (Danio rerio) by Nastasia Popowycz, Leen Uyttebroek, Jean-Pierre Timmermans, Luc Van Nassauw (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13241855.txt.
Description
Popowycz, Uyttebroek, Timmermans, and Van Nassauw show a gene is essential for correct neuron mixes in the zebrafish gut brain, in a study from twenty twenty-six. The gut nervous system controls digestion and develops under transcription factors. The factor Ascl1a's role in fish gut neurons was unclear. The team tracks its expression and deletes it in mutant larvae.
Expression peaks at three days after fertilization in the gut. Without the gene, gut neurons appear late and in far lower numbers. Serotonergic neurons rise while calbindin neurons fall and arrive late. Nitrergic neuron shares stay unchanged. The gene thus shapes both timing and subtype balance in gut development.
Catalog record
| CREATOR | Nastasia Popowycz, Leen Uyttebroek, Jean-Pierre Timmermans, Luc Van Nassauw |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |