Integrated Stress Response and Necroptosis Drive Epithelial Dysfunction in Crohn’s Disease: Repurposing Cancer Drugs for Permeability Barrier Healing
Debasish Halder, Ritwika Biswas Lanford, Amin Esmaeilniakooshkghazi, Jason Ken Hou, Yaohong Wang, Seema Khurana · 2026
Read Integrated Stress Response and Necroptosis Drive Epithelial Dysfunction in Crohn’s Disease: Repurposing Cancer Drugs for Permeability Barrier Healing by Debasish Halder, Ritwika Biswas Lanford, Amin Esmaeilniakooshkghazi, Jason Ken Hou, Yaohong Wang, Seema Khurana (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13241844.txt.
Description
Debasish Halder and co-authors report a 2026 study on healing the gut barrier in Crohn disease. Current drugs calm inflammation but do not repair the leaky intestinal lining. Barrier healing, the authors note, tracks with long-term remission better than surface healing alone.
Two injury pathways were targeted together: a cell stress response and a form of cell death driven by a protein called RIPK3. In two mouse models and in gut organoids grown from patients, both pathways were overactive and damaged the lining. Blocking either pathway restored tissue structure, improved survival and regrowth of lining cells, and raised barrier tightness. Two approved cancer drugs worked as blockers, suggesting a repurposing path.
Catalog record
| CREATOR | Debasish Halder, Ritwika Biswas Lanford, Amin Esmaeilniakooshkghazi, Jason Ken Hou, Yaohong Wang, Seema Khurana |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |