Effects of antidepressant medications on brain tissue microstructure in persistent depressive disorder across two randomized controlled trials
Ravi Bansal, David J. Hellerstein, Siddhant Sawardekar, Ying Chen, Bradley S. Peterson · 2026
Read Effects of antidepressant medications on brain tissue microstructure in persistent depressive disorder across two randomized controlled trials by Ravi Bansal, David J. Hellerstein, Siddhant Sawardekar, Ying Chen, Bradley S. Peterson (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13241746.txt.
Description
Ravi Bansal and co-authors report a 2026 brain imaging study from two randomized trials in persistent depressive disorder. Participants received antidepressant medication or placebo, with diffusion imaging scans before and after treatment. The scans track tiny structural features of brain tissue.
Those measures moved toward normal values in the medication groups but not in the placebo groups. As symptoms eased, the tissue patterns linked to the disorder faded. The authors interpret the changes as a reduced need for compensatory adjustments in the brain once medication works. Persistent depression can last for years, so evidence of measurable brain change matters. The findings support biological effects of antidepressants beyond symptom scores alone.
Catalog record
| CREATOR | Ravi Bansal, David J. Hellerstein, Siddhant Sawardekar, Ying Chen, Bradley S. Peterson |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |