An Integrative Proteomic Approach to Reveal Altered Signaling Modules During Alzheimer’s Disease Progression in PS19 Tauopathy Mice
Eunji Cho, Seulah Lee, Hagyeong Lee, Jaehoon Kim, Yang Woo Kwon, Hyang-Sook Hoe, Dayea Kim, Jong Hyuk Yoon · 2026
Read An Integrative Proteomic Approach to Reveal Altered Signaling Modules During Alzheimer’s Disease Progression in PS19 Tauopathy Mice by Eunji Cho, Seulah Lee, Hagyeong Lee, Jaehoon Kim, Yang Woo Kwon, Hyang-Sook Hoe, Dayea Kim, Jong Hyuk Yoon (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13241738.txt.
Description
Eunji Cho and co-authors use an integrative proteomic approach to reveal signaling modules that change as Alzheimer's disease progresses in tauopathy mice. Their 2026 study profiles seven brain regions.
The disease brings cognitive and behavioral decline, with amyloid plaques and tau tangles building up over time. Neurotransmitter systems such as dopamine also fail, yet joint profiling of transmitters and proteins was limited. The team measured proteomes and neurotransmitters in mice aged four to seven months, a window of progression. Protein changes were significant across regions. Linking the two layers should show which signaling modules falter first as tau pathology spreads.
Catalog record
| CREATOR | Eunji Cho, Seulah Lee, Hagyeong Lee, Jaehoon Kim, Yang Woo Kwon, Hyang-Sook Hoe, Dayea Kim, Jong Hyuk Yoon |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |