Timosaponin B-II attenuates hemorrhagic transformation-driven acceleration of alzheimer disease-related pathology after ischemic stroke
Yafen Dong, Xuesong Bai, Ye Chen, Jian Wang, Qiaoyan Cui, Liming Fan, Shushu Li, Yan Qiu · 2026
Read Timosaponin B-II attenuates hemorrhagic transformation-driven acceleration of alzheimer disease-related pathology after ischemic stroke by Yafen Dong, Xuesong Bai, Ye Chen, Jian Wang, Qiaoyan Cui, Liming Fan, Shushu Li, Yan Qiu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13241655.txt.
Description
Yafen Dong and co-authors report a 2026 mouse study linking bleeding after stroke to faster Alzheimer-type brain changes. Bleeding into treated stroke tissue is a known risk of clot-removal therapy. Whether it speeds existing Alzheimer pathology was unclear.
In mice carrying early Alzheimer-related genes, bleeding after a temporary artery blockage worsened memory and raised amyloid buildup. A plant-derived compound, timosaponin B-II, reduced those effects. Cell experiments showed the compound protected energy-producing structures and lowered cell death signals. It worked through a protective gene switch that curbed amyloid production. The authors propose the compound as a candidate for limiting Alzheimer acceleration after complicated stroke recovery.
Catalog record
| CREATOR | Yafen Dong, Xuesong Bai, Ye Chen, Jian Wang, Qiaoyan Cui, Liming Fan, Shushu Li, Yan Qiu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |