PKA signaling modulates PRMT5/hnRNP A1-mediated IRES translation and dictates responses to mTOR inhibition in glioblastoma
Sunil Kumar, Angelica Benavides-Serrato, Jacquelyn T Saunders, Robert N Nishimura, Joseph F Gera · 2026
Read PKA signaling modulates PRMT5/hnRNP A1-mediated IRES translation and dictates responses to mTOR inhibition in glioblastoma by Sunil Kumar, Angelica Benavides-Serrato, Jacquelyn T Saunders, Robert N Nishimura, Joseph F Gera (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13241469.txt.
Description
Kumar and colleagues at the Los Angeles VA uncovered how glioblastoma dodges mTOR-blocking drugs. Tumors keep making growth proteins through a backup internal ribosome entry route. A screening assay fished out protein kinase A as partner to the methylation enzyme PRMT5. Cell and mouse-brain tumor experiments tested the partnership.
The kinase stamps PRMT5 with a phosphate that lets it grip and methylate its partner protein. That grip switches on the backup translation of cyclin and myc messages. Blocking kinase and mTOR together killed tumor cells and shrank grafted tumors. Kumar proposes the dual blockade as a resistance-breaking strategy.
Catalog record
| CREATOR | Sunil Kumar, Angelica Benavides-Serrato, Jacquelyn T Saunders, Robert N Nishimura, Joseph F Gera |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |