LncRNA TUG1 promotes hypertrophic scar formation via the miR-627/IGF1R axis
Zeming Bai, Ziyang Han, Xiangzi Kong, Rirui Zhao, Haiwei Sun, Hai Huang, GuYue Wang, Zhe Li, Kai Tao, Jiulong Liang · 2026
Read LncRNA TUG1 promotes hypertrophic scar formation via the miR-627/IGF1R axis by Zeming Bai, Ziyang Han, Xiangzi Kong, Rirui Zhao, Haiwei Sun, Hai Huang, GuYue Wang, Zhe Li, Kai Tao, Jiulong Liang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13241453.txt.
Description
Bai and colleagues in Shenyang traced a molecular chain that drives hypertrophic scars after burns and wounds. The long noncoding RNA TUG1 runs high in scar tissue. Levels of its partner microRNA run correspondingly low. Expression assays, cell experiments, and a rabbit ear model tested the axis.
TUG1 sponges the microRNA, freeing the growth receptor IGF1R from repression. Freed fibroblasts then proliferate and migrate faster, laying down more collagen. Adding the microRNA back reversed these effects in cells and animals alike. Bai nominates the axis as a drug target for fibrotic skin disease.
Catalog record
| CREATOR | Zeming Bai, Ziyang Han, Xiangzi Kong, Rirui Zhao, Haiwei Sun, Hai Huang, GuYue Wang, Zhe Li, Kai Tao, Jiulong Liang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |