Spatiotemporal modeling of tau aggregation following traumatic brain injury: implications for chronic traumatic encephalopathy
José González-Cabrero, Carlos G. S. Cardoso, Inés Moreno-González, Ricardo J. Alves-de-Sousa · 2026
Read Spatiotemporal modeling of tau aggregation following traumatic brain injury: implications for chronic traumatic encephalopathy by José González-Cabrero, Carlos G. S. Cardoso, Inés Moreno-González, Ricardo J. Alves-de-Sousa (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13241446.txt.
Description
González-Cabrero's team at Aveiro borrowed a crystal-growth law to chart tau spread after head injury. Repeated blows seed the tau tangles of chronic traumatic encephalopathy by unknown means. Their Avrami-style model treats clumps as seeding, then growing over time. Mouse tau-disease data set the timing.
Strain maps from mock impacts pinpointed where change should run fastest. High-strain regions indeed seeded tau damage sooner in the model. The output flags strain-prone brain areas for closer study. The authors present a numbers bridge from impact physics to disease course. It links hit strength to later harm.
Catalog record
| CREATOR | José González-Cabrero, Carlos G. S. Cardoso, Inés Moreno-González, Ricardo J. Alves-de-Sousa |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 92 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |