Comparative Analysis of Dual‐miRNA Mediated Stimulation of Nucleus Pulposus and Bone Marrow Derived Stem Cells for Intervertebral Disc Repair
Tara Ní Néill, Niamh Wilson, Jake McDonnell, Fergal J O'Brien, Caroline M Curtin, James E Dixon, Pieter A J Brama, Conor T Buckley · 2026
Read Comparative Analysis of Dual‐miRNA Mediated Stimulation of Nucleus Pulposus and Bone Marrow Derived Stem Cells for Intervertebral Disc Repair by Tara Ní Néill, Niamh Wilson, Jake McDonnell, Fergal J O'Brien, Caroline M Curtin, James E Dixon, Pieter A J Brama, Conor T Buckley (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13241378.txt.
Description
Néill and colleagues at Trinity College Dublin compared two cell sources for repairing degenerated spinal discs with microRNA therapy. Their treatment pairs a microRNA mimic with an inhibitor to calm matrix breakdown. Goat cells and whole disc organ cultures modeled the human condition. Native disc cells faced off against bone marrow stem cells.
Both cell types quieted the matrix-chewing enzymes and inflammatory signals. Only native disc cells, though, ramped up fresh matrix markers inside cultured discs. Marrow stem cells delivered to the same organs showed no such response. Néill backs the disc's own cells as the delivery vehicle.
Catalog record
| CREATOR | Tara Ní Néill, Niamh Wilson, Jake McDonnell, Fergal J O'Brien, Caroline M Curtin, James E Dixon, Pieter A J Brama, Conor T Buckley |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |