Proteomic signatures of renal recovery from acute kidney injury—a translational study in critically ill postoperative patients
Thilo von Groote, Moritz J. Mertes, Hendrik Booke, Mahan Sadjadi, Christian Strauß, Katrin Schützenmeister, Christian Porschen, Amélie Friederike Menke, Harm-Jan de Grooth, Lui G. Forni, Melanie Meersch-Dini, Simone König, Alexander Zarbock · 2026
Read Proteomic signatures of renal recovery from acute kidney injury—a translational study in critically ill postoperative patients by Thilo von Groote, Moritz J. Mertes, Hendrik Booke, Mahan Sadjadi, Christian Strauß, Katrin Schützenmeister, Christian Porschen, Amélie Friederike Menke, Harm-Jan de Grooth, Lui G. Forni, Melanie Meersch-Dini, Simone König, Alexander Zarbock (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13241338.txt.
Description
von Groote and colleagues in Münster searched blood proteins for signs that acute kidney injury will turn chronic. Their prospective cohort enrolled two hundred five critically ill postoperative patients with moderate injury. Plasma from one hundred ninety-five patients underwent high-resolution mass spectrometry. The outcome was persistent injury or death within a week.
Just over half the patients progressed to acute kidney disease. Dozens of proteins tracked with progression across depleted and undepleted plasma. Calprotectin stood out strongest, and a targeted assay confirmed higher levels in progressors. The authors propose it as a candidate marker of kidney injury chronification.
Catalog record
| CREATOR | Thilo von Groote, Moritz J. Mertes, Hendrik Booke, Mahan Sadjadi, Christian Strauß, Katrin Schützenmeister, Christian Porschen, Amélie Friederike Menke, Harm-Jan de Grooth, Lui G. Forni, Melanie Meersch-Dini, Simone König, Alexander Zarbock |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |